ABSTRACT
To explore the clinical efficacies of narrow-band ultraviolet B (NB-UVB) for atopic dermatitis (AD).Thirty AD patients (observation group) and 30 homochromous healthy volunteers (control group) were compared.The post-treatment scores of Scoring AD (SCORAD) and visual analogue scale (VAS) [(29.4 ± 9.5) & (3.2 ± 1.1) points] were lower significantly those pre-treatment [(60.7 ± 11.4) & 6.3 ± 1.6) points] (P ＜ 0.01).The pre and post-treatment serum levels of 25 (OH) D3 and 1,25 (OH)2D3 were detected with enzyme-linked immunosorbent assay (ELISA).The post-treatment serum levels of 25 (OH) D3 and 1,25 (OH) 2 D3 [(75.36 ± 23.28) mmol/L & (149.28 ± 45.56) nmol/L] were significantly higher than those pre-treatment in observation group [(36.24 ± 18.48) mmol/L & (97.68 ± 32.88)nmol/L] (P ＜0.01).There were no significant differences from those in group control[(69.84 ± 20.64) mmol/L & (147.36 ± 43.68) nmol/L] (P ＞ 0.05).And the pre-treatment serum levels of 25 (OH) D3 and 1,25 (OH)2D3 were all significantly lower in observation group than those in control group (P ＜ 0.01).Thus NB-UVB therapy is both safe and effective for AD and it can boost significantly the serum level of vitamin D3.
ABSTRACT
Objective To evaluate the clinical efficacy and safety about carbon dioxide fractional laser combined with liquid nitrogen cryotherapy for flat warts.Methods Eighty-three patients with flat warts were divided into 2 groups according to the treatment method,42 patients in treatment group were treated by carbon dioxide fractional laser combined with liquid nitrogen cryotherapy,41 patients in control group were treated by liquid nitrogen cryotherapy alone.As a period for 10 days,2 groups were given 2 periods of treatment.The therapeutic effect,recurrence rate and adverse reaction were compared between 2 groups.Results The cure rates of 1-period and 2-period in treatment group were significantly higher than those in control group [73.81％(31/42) vs.46.34％(19/41) and 97.62％(41/42) vs.75.61％(31/41)],the recurrence rate and incidence of adverse reaction in treatment group were significantly lower than those in control group [2.44％(1/41) vs.19.35％(6/31) and 9.52％(4/42) vs.31.71％(13/41)],there were statistical differences (P ＜ 0.05 or ＜ 0.01).Conclusion Carbon dioxide fractional laser combined with liquid nitrogen cryotherapy for fiat warts is a safe and effective treatment with low recurrence rate.